Researchers have found that higher levels of testosterone may help reduce the risk of type 2 diabetes in men under the age of 65 who are overweight or obese. However, this benefit does not seem to apply to men over the age of 65, who may need to explore other ways to manage their diabetes risk. The study, presented at ENDO 2024, was conducted by researchers from the University of Adelaide in Australia, who aimed to better understand the relationship between testosterone levels and type 2 diabetes risk in men of different age groups. They found that low blood testosterone concentration is an independent risk factor for developing type 2 diabetes, while high levels of testosterone may be protective.
The researchers examined data from the MAILES Cohort, a group of men living in urban Adelaide aged 35 to 85 years, who were initially free of testosterone treatment, diabetes, or cancer. After a five-year follow-up period, 110 of the men had developed type 2 diabetes. The study corrected for factors known to influence the risk of developing type 2 diabetes, such as smoking, alcohol use, age, waist circumference, family history of diabetes, blood sugar levels, medication use, and physical activity. The findings indicated that higher testosterone levels were associated with a reduced risk of developing type 2 diabetes before the age of 65, but no significant effect was observed in men over the age of 65.
Maintaining a healthy weight, regular exercise, and avoiding excessive alcohol consumption were highlighted as ways to help men maintain normal testosterone levels and prevent type 2 diabetes. Dr. Steve Gendron, an expert in immunology and endocrinology, explained that testosterone naturally decreases with age, making it more challenging for older men to fend off conditions like type 2 diabetes. He emphasized the importance of a holistic approach to managing diabetes risk and suggested that men consult with healthcare providers before considering testosterone supplementation, as it may not always be the best course of action.
Dr. Jamin Brahmbhatt, a urologist at Orlando Health, emphasized the importance of consulting with a healthcare provider before taking testosterone supplements, as testosterone levels can naturally decline with age and may be affected by comorbidities and metabolic changes. He pointed out that higher levels of testosterone can improve insulin sensitivity and reduce fat mass, both of which are crucial for preventing type 2 diabetes. Brahmbhatt encouraged men to focus on maintaining a healthy lifestyle, including regular physical activity, a balanced diet, and moderate alcohol consumption, to help offset the increased risk of type 2 diabetes as testosterone declines after age 65.
As more research emerges on the role of testosterone in diabetes prevention, experts anticipate that guidelines may evolve to consider broader indications for testosterone replacement therapy. Gendron emphasized the importance of a multifaceted approach to health, including staying active, eating well, seeking regular medical check-ups, and managing stress. By adopting these foundational health practices, men can work towards preventing type 2 diabetes and maintaining overall well-being throughout their lives.
