Many people prescribed weight loss drugs such as Wegovy and Saxenda stop taking them before reaching 12 weeks or the target dose. Research conducted by Blue Shield revealed that more than half of the individuals studied quit these medications before the 12-week mark. The study found that 30% of people stopped treatment within four weeks before they had reached their target dose. This discontinuation may impact the effectiveness of these drugs in achieving clinically significant weight loss.
Wegovy and Saxenda are GLP-1 antagonists that mimic a hormone called GLP-1 which regulates blood sugar, reduces hunger, and promotes a feeling of fullness. To get the maximum benefits from these drugs, individuals are encouraged to stay on them for an extended period. These medications need to be taken long term to achieve effective weight loss and reduce the risk of cardiometabolic diseases associated with obesity. However, the Blue Shield research suggests that many individuals do not reach their target dose due to discontinuing the medications prematurely.
Experts emphasize the importance of long-term use of weight loss drugs to achieve significant benefits. Dr. Diana Thiara, the medical director of the UCSF Weight Management Clinic, stated that most patients do not see effective weight loss until they have been on the medications for at least five months. The goal is for patients to stay on these medications for an extended period, beyond 12 weeks, in order to experience the maximum benefits. Dr. Dan Azagury from Stanford University also highlighted the need for continued use until a plateau is reached, where the body adapts to weight loss.
Novo Nordisk, the manufacturer of Wegovy and Saxenda, acknowledged that various factors can impact a person’s adherence to weight loss drugs, including disease bias or stigma, supply constraints, and access to medicines. The company emphasized that obesity is a chronic disease that requires long-term management, much like other conditions such as high blood pressure or high cholesterol. Long-term use of weight loss medications is essential for individuals to continue experiencing the benefits of these drugs.
Cost, healthcare access, obtaining medications, and side effects are some of the reasons why individuals may discontinue the use of weight loss drugs. However, those who are prescribed these medications by specialists such as obesity medicine specialists or endocrinologists are more likely to continue taking them for a longer period. Experts advise individuals who are prescribed weight loss medications to expect long-term treatment to achieve significant benefits and maintain weight loss. It is important for individuals to understand that coming off these drugs may lead to weight regain, underlining the need for prolonged or lifelong use in some cases.
