A recent study by Stanford University researchers has found that the diabetes drug metformin may increase the production of a molecule that suppresses appetite, leading to weight loss benefits. This molecule, known as lac-phe, has anti-hunger effects similar to those produced during vigorous exercise. The study suggests that metformin’s weight loss effects are primarily due to its impact on appetite suppression through the lac-phe molecule, emphasizing the importance of exercise for weight management. Through trials on obese mice and human participants with type 2 diabetes, researchers observed significant increases in lac-phe levels in those taking metformin.
Metformin, marketed under brand names Fortamet and Glumetza, is the most prescribed diabetes medication globally and has been shown to cause modest weight loss in the first few months of treatment. While metformin has not been approved by the FDA for weight loss management, experts agree that it has numerous benefits beyond appetite suppression. Metformin plays a crucial role in regulating blood glucose levels, weight, and overall metabolic function by reducing glucose production in the liver, delaying glucose absorption, promoting earlier satiety, reducing appetite, and enhancing insulin sensitivity. These mechanisms can contribute to modest weight loss by reducing calorie intake and insulin requirements.
However, experts emphasize that metformin is not a standalone weight loss drug and should be combined with lifestyle changes for optimal results. Aimee Jose, a virtual diabetes educator with over 15 years of experience, points out that successful weight management requires a multi-faceted approach that includes regular physical activity and healthy eating habits. Physical activity is particularly important as it improves overall health and supports metabolic function. While metformin can help individuals achieve modest weight loss, sustained results require ongoing commitment to lifestyle changes, including exercise and proper nutrition.
Patients considering or currently taking metformin should be aware of potential digestive side effects associated with the drug. Leslie Sexton, a pharmacist, notes that some individuals may experience gas, bloating, diarrhea, nausea, and increased bowel movements when taking metformin. These side effects typically subside within the first few weeks of treatment but can be minimized by switching to the extended-release formulation of metformin. Sexton advises patients to discuss their options with their healthcare provider and advocate for the extended-release version to reduce discomfort. Lifestyle changes, such as consuming whole foods and engaging in regular exercise, can further support the beneficial effects of metformin for weight management and overall metabolic health.
While newer medications like GLP-1 agonists may offer quick and dramatic weight loss effects compared to metformin, experts emphasize the long-term benefits of metformin in supporting metabolic health. Patients are encouraged to recognize the gradual improvements associated with metformin, especially in blood glucose control and weight management. By combining metformin with exercise, healthy eating, and other supportive lifestyle habits, individuals with type 2 diabetes can achieve sustainable weight loss and improve overall health outcomes. The study highlights the critical role of exercise in weight management and underscores the importance of a holistic approach to managing diabetes and obesity.
