Maintaining a healthy weight involves a combination of healthy eating, regular exercise, and also considering non-modifiable factors such as genetics. A study conducted by researchers from the University of Essex identified 14 “skinny genes” that may work together to help with weight loss. Despite the presence of these genes, a healthy diet and lifestyle are still crucial for losing and maintaining a healthy weight. Genes related to energy metabolism and fat metabolism were found to play a role in weight loss, with the PARGC1A gene being identified as key to weight loss in study participants who lost the most weight.
The study involved 38 adult participants between the ages of 20 and 40 who were randomly assigned to an exercise training group or a control group for eight weeks. All participants were screened for 1,000 gene variants at the end of the study, which helped identify a combination of 14 genes that may improve weight loss. The researchers found that participants in the exercise group who had the most “skinny genes” lost up to 5 kg during the study, while those without them dropped an average of 2 kg. The PARGC1A gene, which encodes PGC-1-a and plays a role in cellular energy metabolism, was identified as a key gene for weight loss.
While having “skinny genes” may assist with the weight loss process, researchers emphasized that it is still important to exercise and eat healthy. They noted that genes alone may not be enough to achieve weight loss without proper interventions. Chung stressed that personalized training strategies are necessary as there is no one-size-fits-all approach to weight loss. The study also pointed out some limitations, including a small sample size and the need for more research into possible interactions between genetics, diet, and obesity.
While genetics play a significant role in determining a person’s weight and body composition, other factors such as diet and exercise are equally important. Dr. Mir Ali, a bariatric surgeon, emphasized that a genetic predisposition to being skinny or overweight does not mean that weight cannot be managed through proper diet and exercise. Eating the right foods and staying physically active are essential for maintaining a healthy weight and avoiding health issues. Dr. Ali also mentioned the importance of determining the optimal diet for different genetic types to help individuals achieve and maintain good health.
Further research is needed to explore the interactions between genetics, diet, and obesity, as well as to develop personalized training strategies for weight loss. Understanding the role of genetics in weight loss can help individuals make informed decisions about their health and wellness. While genetics may influence weight to a certain extent, adopting a healthy lifestyle that includes a balanced diet and regular exercise remains crucial for achieving and maintaining a healthy weight.
