Dionna Williams, a neuroscientist at Emory University, became aware of the disparities in treatment for individuals with HIV who also use illicit or prescription drugs during her Ph.D. studies. These individuals often have worse outcomes related to their HIV progression, viral load, and symptoms. Previously, it was believed that these poor outcomes were due to people not taking their antiretroviral medications. However, Williams questioned this hypothesis, as it seemed unlikely that all individuals with HIV who also use drugs would neglect their treatments. Through their research, Williams has discovered biological reasons behind the negative interaction between HIV medication and drug use.
Williams, who identifies as a nonbinary Black woman, queer, autistic, and first-generation college student, understands the experience of being marginalized and excluded. Their diverse background has contributed to their understanding of different types of people and has made them a better scientist and mentor. Williams’ research, which spans pharmacology, neuroscience, and immunology, uses human samples rather than lab animals, allowing for a more accurate representation of human biology. Despite the challenges of dealing with human variability, Williams is committed to understanding these differences to inform their research.
By working directly with human cells instead of animal models, Williams is able to produce findings that are likely to hold up in human populations. An example of this disparity between animal and human studies can be seen in the activity of genes that detect cannabinoids in different species. While animal studies are commonly used as stand-ins for humans in medical research, Williams’ research has shown that results do not always translate across species. The variation in the location and production of endocannabinoid receptors in different organs highlights the importance of understanding human biology at a deeper level.
Williams’ fearlessness in pursuing research areas where they are not necessarily an expert has set them apart in their field. They are known for their intelligence, creativity, persistence, and tenacity. Williams’ willingness to delve deeper into their research questions and develop the necessary skills and knowledge has enabled them to make significant strides in understanding the interaction between HIV medication and drug use. Their autism has also played a role in their interdisciplinary approach to research, allowing them to see beyond conventional standards and structures in science. Williams’ commitment to exploring new avenues of research and challenging established norms has positioned them as a rising star in the scientific community.
In conclusion, Dionna Williams’ groundbreaking research in the field of neuroscience has shed light on the complex interaction between HIV medication and drug use in marginalized populations. By utilizing human samples and embracing the variability of human biology, Williams has been able to uncover important biological mechanisms that influence treatment outcomes for individuals with HIV who use drugs. Their fearless pursuit of interdisciplinary research, along with their unique perspective as an individual with multiple marginalized identities, has positioned them as a highly influential and respected scientist in their field. Williams’ dedication to understanding human complexities and pushing the boundaries of scientific inquiry serves as an inspiration to researchers and advocates for marginalized communities worldwide.
